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Complement Project
Systemic complement is produced by the liver and travels via the blood to distant sites. While locally, within a tumor, tumor cells, T cells, and endothelial cells can all produce complement that acts either in an autocrine or paracrine fashion.
The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. The mechanisms by which complement is activated and affects tumor progression are not well understood. We aim to determine the role of complement in tumor progression and investigate complement inhibitors as a novel therapeutic strategy for lung cancer.
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