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Eicosanoids
Eicosanoids, including Prostaglandins, produced by cyclooxygenases (COX), and leukotrienes, produced by 5-lipoxygenase (5-LO) are implicated in cancer progression. These molecules are produced by both cancer cells and the tumor microenvironment (TME). The major goal of this project is to identify the contribution of eicosanoids produced by cancer cells and the microenvironment to lung cancer progression.
Individual cell types in the tumor microenvironment produce distinct panels of eicosanoid as a consequence of cell-specific expression of enzymes in this pathway.
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